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Senior Research Associate

Company: Agenus Inc.
Location: Berkeley
Posted on: September 13, 2020

Job Description:

?We are a dedicated group of scientists, physicians, and businesspeople working together toward one goal: to discover and develop therapies that can unleash the power of the body’s immune system to treat and potentially cure cancer. We are passionate about the work we do every day at Agenus to deliver on the promise of immuno-oncology. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

Senior Research Associate

Agenus is an immuno-oncology company designed to deliver innovation with speed for patients with cancer. We have a unique portfolio of antibodies, vaccines, cell therapies (through our AgenTus Therapeutics subsidiary) and adjuvants designed to treat cancers with optimal combinations. In addition to our broad portfolio, we have an accomplished team of scientists, novel technology platforms and end-to-end capabilities from new target discovery to GMP manufacturing. We believe that combination therapies and a deep understanding of each patient’s cancer will be key drivers of success in substantially expanding the patient population benefiting from current immuno-oncology therapies. At Agenus, we believe we have assembled the capabilities to bring curative treatments to patients.

Who are we looking for?

An enthusiastic and knowledgeable Senior Research Associate to join our Cell Engineering team

A colleague that can leverage their industry and or academic knowledge and experience in molecular engineering to develop systems that support our pipeline programs

A colleague who is adept at working on multiple projects in a fast-paced environment

An individual with a desire to learn, trouble shoot technical problems and work as part of a team

What are we looking for?

Creativity : Innovative thinker and learning-agile team member

Ownership : A partner to jointly own our company’s goals, execution and success

Working together : A colleague to thrive in collaboration with our global teammates

Loving what you do : A team member with positive energy that is passionate about our mission

Engagement : An active participant that enjoys sharing ideas, contributing with others, and engaging in our projects and process improvements.

What are we offering?

A dynamic, fun and learning culture

Exposure to pioneering science and the full drug development process

A team with experience and passion about science

A unique opportunity to help develop the platforms and strategy of a burgeoning company

Career support and learning opportunities within Agenus

Membership within a growing, dynamic and collegial organization

Advanced technologies and potential for cross-training across different functional groups

Job Responsibilities

This position will primarily focus on cloning and expression of recombinant proteins in mammalian cells as well as utilizing gene editing tools for engineering CHO cells. The successful candidate will clone different antibody formats and proteins into mammalian expression vectors and evaluate their potential using transient transfections and stable cell line development. The analysis will continue into cell culturing and analytical-scale production. Experience in diverse molecular biology techniques, mammalian cell culture procedures, as well as methods for small scale protein purification and analysis is required.

Roles and Responsibilities

Use DNA/RNA/protein analysis software to design and clone expression vectors using a variety of techniques including restriction/ligation, LIC, SLIC, Gibson, Infusion and Golden Gate

Participate in designing and implementing CHO genome editing using Cas9 based or other recombinant techniques

Perform small to large scale transient production of recombinant antibodies or other proteins in CHO or HEK293 expression systems

Analyze proteins using Octet, ELISA, Western blotting and other techniques such as PAGE and SEC

Grow and maintain attached or suspension cells and prepare cell banks

Participate in stable cell line development for GMP manufacturing using instrumentation for single cell cloning, automation and analytics

Participate in planning, designing and testing of targeted transgene integration using non-viral – methods

Maintain accurate data recording in laboratory notebooks

Compile data for technical reports using Microsoft Office and present data at internal team meeting

Maintain laboratory supplies and a safe and clean laboratory environment

Qualifications and Educational Requirements:

BS in Biology, Molecular Biology, Biochemistry, or related field with 5+ years of experience in a biotech environment or MS with 4+ years of experience, or equivalent combination of education and experience.

Supplementary Skills:

Experience with bacterial, yeast or other expression systems

Experience with flow cytometry instrument operation and data analysis

Some knowledge of cGMP manufacturing processes including experience with Ambr bioreactor system

Competency in current molecular biology / gene editing techniques

Strong organizational, time management, communication, and interpersonal skills

Keywords: Agenus Inc., Berkeley , Senior Research Associate, Other , Berkeley, California

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