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Process Development Associate

Company: Caribou Biosciences Inc.
Location: Berkeley
Posted on: September 16, 2022

Job Description:

Caribou is a leading clinical-stage CRISPR genome-editing biopharmaceutical company founded by pioneers in this field. Leveraging our proprietary technologies, we are developing genome-edited, off-the-shelf immune cell therapies for the treatment of patients with devastating human diseases, including cancer. We believe that cell therapies are critical now and for the future of cancer therapeutics, and that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies. We are developing a pipeline of wholly-owned, genome-edited, off-the-shelf CAR-T and CAR-NK cell therapy product candidates for a range of tumor types. Caribou's headquarters are in Berkeley, California.

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.

We are seeking an enthusiastic and motivated cell therapy Process Development Associate to join our team in Berkeley. In this role you will interact with team members across the organization and provide

Our collaborative and fun Process Development team is seeking an experienced and knowledgeable Process Development Associate to join us in Berkeley, California. This is an exciting opportunity to interact with team members cross-functionally and provide support to optimize Caribou's platform manufacturing process for gene-edited cell therapies. In this role you'll have the opportunity to use your skill set to solve challenges, optimize processes, and transfer technologies to GMP.

Responsibilities include:

* Develop cGMP-compatible CAR-T cell separation, cell enrichment, cell expansion, gene editing, final formulation and related processes for scale-up
* Use engineering principles to leverage bench and pilot scale models for cell therapy manufacturing process performance characterization
* Participate in technical transfer of technologies to CMO/ and provide training and on-going technical support
* Design and execute characterization studies, evaluate product impact of scale-up and/or raw material changes
* Optimize scale-up of operations compatible with applicable quality assurance guidelines
* Generate development reports and prepare SOPs and batch records
* Participate in cross-functional teams, working in a highly matrixed team environment to advance preclinical program

Qualifications:

* Bachelor's or Master's degree in Biology or a related field
* Minimum of 2 years of experience in pharma or biotech, preferably in process development
* Experience with cell culture, cell-based assays and a working knowledge of cell biology/immunology
* Must be familiar with GMP- Manufacturing

Nice-to-haves:

* Experience with CAR-T cell process development
* Experience with multi-color flow cytometry
* Experience interacting with CMO partners
* Background in immunology or immune cell engineering
* Experience developing and tech transferring cell therapies toward GMP-Manufacturing
* Experience with statistical design of experiments, advanced data analysis and Quality by Design concepts

Caribou compensation and benefits include:

* Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
* Generous paid vacation time, in addition to company-observed holidays and floating holidays
* Excellent medical, dental, and vision insurance
* 401(k) retirement savings plan, which includes matching employer contributions
* Tuition reimbursement program

Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.

For more information about Caribou, visit www.cariboubio.com and follow the company @CaribouBio.

Keywords: Caribou Biosciences Inc., Berkeley , Process Development Associate, Other , Berkeley, California

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