Senior Principal Scientist / Distinguished Scientist - Structural Biology

Company: Genentech
Location: Berkeley
Posted on: January 18, 2023

Job Description:

The PositionThe Genentech Structural Biology Department integrates macromolecular crystallography, CryoEM, and NMR spectroscopy to both drive drug discovery as well as uncover fundamental biology. We explore the structural and functional properties of proteins of therapeutic interest, and their interactions with ligands, substrates, and binding partners. Our group designs constructs, purifies proteins, and then analyzes their structures and molecular interactions. - -We collaborate with scientists throughout the Research organization to advance both traditional "small molecule" and protein-based drug discovery as well as to pursue basic research questions regarding structure and function.Who you are:Macromolecular structural biologist with outstanding experience in all aspects of structure determination, from construct design through refinement, interested in joining a multi-disciplinary structural biology department, to pursue drug design and to perform groundbreaking research. - -A key requirement is a track record of working with chemistry teams in structure based drug design.Requirements:Ph.D. in structural biology, biophysics, biochemistry or related discipline, relevant post doctoral experience, and 10-15 years additional experience as an independent scientific investigator or group leader. Knowledge of protein purification, fundamental biochemistry, and a strong publication record in top tier journals as well as significant technical expertise in determining X-ray crystalstructure and CryoEM structures is required. Significant (10+ years of) prior experience working with protein:ligand complexes for mechanistic studies and/or drug discovery are required. Facility with standard software related to structure determination and data presentation is expected. As this position interfaces with multiple groups at Genentech, high quality verbal, written, and presentationskills are essential.** Please include a cover letter with your resume submission **#scientistjob#LI-GD2Relocation benefits are available for this job postingThe expected salary range for this position based on the primary location of California is $168,00-$313,000. - Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. - A discretionary annual bonus may be available based on individual and Company performance. - This position also qualifies for the benefits detailed at the link provided below.Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. - If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.Job Facts JOB FUNCTION COMPANY/DIVISION Genentech SCHEDULE JOB TYPE Full time

Keywords: Genentech, Berkeley , Senior Principal Scientist / Distinguished Scientist - Structural Biology, Other , Berkeley, California