Biochemist Scientist, Drug Discovery Technology
Company: Carmot Therapeutics
Location: Berkeley
Posted on: January 24, 2023
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Job Description:
Carmot Therapeutics, Inc. is a biotech company focused on the
discovery of innovative drugs for the treatment of metabolic
diseases and cancer. Carmot is expanding the frontiers of drug
discovery through application of its Chemotype Evolution platform
to advance new treatments for metabolic disease and oncology
affecting millions of patients in need.Carmot is seeking a
Biochemist to join our Drug Discovery Technology Team and help
leverage and expand exciting applications of the Chemotype
Evolution platform. In this research position you will play a
central role in applying Chemotype Evolution to identify and
optimize novel drug leads for internal or partnered
programsPosition SummaryThe successful candidate will design,
qualify, and execute biochemical assays for target-based, high
throughput drug discovery programs powered by our core platform
Chemotype Evolution. Working closely with scientists in biology and
chemistry as part of a multidisciplinary team, the candidate will
have to integrate diverse chemical and biological data to
accelerate lead discovery. In this position you will be working in
an exciting, innovative environment. The ideal candidate is a
team-player, motivated by novel challenges and enthusiastically
pursues creative solutions to achieve common goals.Primary
responsibilities+ Design biochemical and biophysical assays based
on literature precedents and/or experience according to program
needs + Optimize, validate, and troubleshoot assays for robustness,
sensitivity, and reproducibility to enable implementation for
high-throughput screening+ Perform compound screening in
biochemical assays working with high-throughput workflows+ Monitor
assay data quality and ensure assay data is communicated to project
team in a clear and timely manner+ Design MOA studies necessary to
understand molecular details for the activity of key lead series+
Regular presentation of research progress at internal meetings and
with external collaboratorsRequired experience and skills+ PhD, or
MS with industry experience, in biochemistry, chemical biology, or
related field+ Understanding of methods to determine mechanism of
action for small molecule activators/inhibitors of enzyme activity,
including covalent molecules+ Broad knowledge of enzyme targets,
including kinetics of multi-substrate enzymes+ Demonstrated
understanding of quality parameters in assay development and
optimization+ Prior experience with drug discovery and compound
screening using biochemical and/or cell-based assays is desirable+
Excellent communication, organization and data analysis
skillsCarmot offers competitive salary, participation in our stock
option plan, 401k retirement, and comprehensive benefits. This
position is located onsite in Berkeley, CA. Must be authorized to
work for any employer in the U.S.Carmot Therapeutics, Inc. is
committed to equal employment opportunity, regardless of age,
ancestry, color, disability (mental and physical), exercising the
right to family care and medical leave, gender, gender expression,
gender identity, genetic information, marital status, medical
condition, military or veteran status, national origin, political
affiliation, race, religious creed, sex (includes pregnancy,
childbirth, breastfeeding and related medical conditions), and
sexual orientation.
Keywords: Carmot Therapeutics, Berkeley , Biochemist Scientist, Drug Discovery Technology, Other , Berkeley, California
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