Associate Biochemist - Gene Therapy

Company: EUROFINS SCIENT.
Location: Berkeley
Posted on: January 27, 2023

Job Description:

Consider joining Eurofins Lancaster Laboratories where people are the most important element in our chemistry. Eurofins is a leading international group of laboratories providing an unparalleled range of testing and support services to the pharmaceutical, biopharmaceutical, food, environmental, and consumer products industries and to governments. Eurofins Lancaster Laboratories, a nationally recognized laboratory, is searching for an Associate Biochemist - Gene Therapy fto support our Professional Scientific Services group in Berkeley, CA. Associate Biochemist responsibilities include, but are not limited to, the following: * Performs and conducts bench scale gene therapy Adeno-Associated virus (AAV) vector purification development experiments independently (e.g. buffer preparation, chromatography, tangential flow filtration, unit operation procedures, assays, etc.) with general guidance and instruction
* Evaluates new methods, technologies, and equipment as required for AAV viral vector and monoclonal antibody purification to facilitate and improve process development
* Designs AAV purification experiments, data analysis, trouble shooting, protocol and report writing under the direction of the development lead scientist
* Executes pilot scale-up AAV viral vector purification runs and supports clinical manufacturing operations under GMP conditions, as needed
* Exercises judgment within defined practices and policies in determining appropriate action, and is capable of understanding technical literature for problem solving
* Communicates scientific findings, provides status updates on assigned tasks in one-on-one discussions and within the project team and department meetings
* Contributes to the functions of the laboratory including ordering, organization, chemical and equipment monitoring, and maintenance The ideal candidate would possess: * Ability to understand and execute bench scale purification development techniques including chromatography using AKTA and Avant workstations, dead-end filtration, tangential flow filtration, and various protein and viral vector analytical assays such as SDS-PAGE, Western Blotting, UV-Vis Spectrophotometry, HPLC, qPCR, ELISA, DLS, and HTRF
* Understands basic GMP requirements
* Familiar with statistical software such as JMP for data analysis
* Experience with Design of Experiment (DOE), automation, database construction and analysis
* Experience working with automated liquid handler (e.g. Tecan) and automated UFDF systems (e.g. AKTA Crossflow and AKTA Flux)
* Bachelor degree in chemistry, biology, or other related degree concentration
* 1-3 years of relevant experience (BS degree) or 0-1 year of relevant experience (MS degree)
* Authorization to work in the United States indefinitely without restriction or sponsorship Position is full-time, Monday through Friday (8 a.m.-5 p.m.), with overtime as needed. Candidates currently living within a commutable distance of Berkeley, California are encouraged to apply. As a Eurofins Lancaster Lab PSS employee, you will become part of a company that has received national recognition as a great place to work. We offer excellent full-time benefits including comprehensive medical coverage, life and disability insurance, 401(k) with company match, paid holidays and vacation, personal days, and dental and vision options. To learn more about Eurofins Lancaster Laboratories, please explore our website . Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.

Keywords: EUROFINS SCIENT., Berkeley , Associate Biochemist - Gene Therapy, Other , Berkeley, California